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February 22, 1985

Bone Marrow: Structure and Function

JAMA. 1985;253(8):1183. doi:10.1001/jama.1985.03350320109037

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This is a well-written, up-to-date, concise text of bone marrow morphology (structure) and physiology (function). In 14 concise chapters, the authors review bone marrow phylogeny, ontogeny, structure, marrow circulation, marrow-blood barrier, marrow volume, population of cells, granulocyte production, erythropoiesis, thrombopoiesis, lymphopoiesis, stem cell compartments, and the role of stem cells. The text is authoritative and the references are up-to-date. The chapter on historic perspectives is a delight to read. One can learn how the bone marrow's function was finally deduced.

My only criticism is that the references should be listed on a chapter-to-chapter basis, rather than all together.

Hematologists and physicians in postgraduate training programs in hematology will find this textbook a valuable addition to their libraries.