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March 1, 1985

Serological Response to Syphilis Treatment: A New Analysis of Old Data

Author Affiliations

From the Division of Sexually Transmitted Diseases, Center for Prevention Services (Drs Brown and Reynolds and Mr Zaidi); and the Sexually Transmitted Diseases Laboratory Program, Center for Infectious Diseases (Dr Larsen), Centers for Disease Control, Atlanta.

JAMA. 1985;253(9):1296-1299. doi:10.1001/jama.1985.03350330094030

One important aspect of the posttreatment evaluation of patients with early syphilis is assessment of serological test results. Using information previously collected from 818 patients in the Early Syphilis Study, we evaluated the seroresponse of people treated for primary or secondary syphilis. We generated curves describing the VDRL titer declines with time. The VDRL titer declined approximately fourfold at three months and eightfold at six months. These observations will allow clinicians to identify treatment failures or reinfections at the earliest possible time during their follow-up.

(JAMA 1985;253:1296-1299)