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Although "the book is aimed at clinicians and statisticians alike," the orientation is that of persons who have worked in a multi-institutional, cooperative effort. As a result, the title is somewhat misleading, since the perspective of a major cancer center or an academic university center is not comprehensively included.
The major strength of the publication lies in Part VII, which has six separate authors contributing to the analysis of phase III trials. This section gives a good introduction to the methodology used for analysis, includes summaries of some recent results, and contains good references. There are good chapters on methods for estimating and comparing proportions using primarily x2 tests, calculation and interpretation of survival curves, tests for comparing survival curves, and problems associated with interim analyses. There is also a fairly comprehensive chapter by Byar on prognostic factors. The final contribution to this part includes the use of regression
Freireich EJ, Gehan EA. Cancer Clinical Trials: Methods and Practice. JAMA. 1985;253(10):1466–1467. doi:10.1001/jama.1985.03350340120038
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