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October 11, 1985

Migration of Polytetrafluoroethylene—Polytef

JAMA. 1985;254(14):1902. doi:10.1001/jama.1985.03360140054011

To the Editor.—  I read the article by Malizia et al1 with more than a passing interest, since I initiated the concept and described the technique of polytef injection for urinary incontinence.2It is common knowledge that any injected particle, whether polytef or charcoal, will migrate to regional nodes and distant places. We observed this in our initial studies in dogs and again in later studies in guinea pigs in which migration of polytef paste, floc, and microstrands were compared. All materials migrated in varying amounts. The issue, then, is not the migration of particles, for they indeed do migrate. The issue is whether the particles that remain at the injection site, or that migrate, produce any harm. Prosthetic devices, such as penile implants, artificial sphincters, valves, and vessel replacements are being used in increasing numbers. There is a constant reaction between the prosthetic device and adjacent tissue