To the Editor.—
In the article entitled "Migration and Granulomatous Reaction After Periurethral Injection of Polytef (Teflon)" in the June 22/29, 1984, issue of JAMA, the authors conclude by stating, "Our opinion is that this substance should not be given to children or young adults with normal life expectancy until its long-term effects in humans are known." This is a surprisingly broad conclusion from an elegant but limited piece of experimental work. The authors do not even suggest that further experimental work is required. They cite a reference2 reporting an instance (the first recorded) of polytef granulomas found in the lungs of a patient who had received two periurethral injections of polytef paste (10- to 15-mL second injection) two years and one year before his death by suicide. In the cited reference, it is noted that the polytef particles reached the pulmonary circulation via the prostatic venous plexus and
O'Donnell B, Puri P. Migration of Polytetrafluoroethylene—Polytef. JAMA. 1985;254(14):1902–1903. doi:10.1001/jama.1985.03360140054012
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