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October 25, 1985


JAMA. 1985;254(16):2291-2293. doi:10.1001/jama.1985.03360160123030

Major research advances during the past two decades have contributed enormously to the improved survival of high-risk newborn infants. The achievements of neonatal investigators during the past two years have been equally productive. This discussion attempts to highlight some of the significant research accomplishments that directly or indirectly have contributed to the improvement of diagnosis and management of neonatal clinical problems. Another facet of these accomplishments is the identification of new areas and directions for investigation in the coming years.

Intraventricular hemorrhage (IVH) is a formidable problem in low-birth-weight infants. Its occurrence compromises the potential for survival. In its severest form, IVH also leads to posthemorrhagic hydrocephalus, which is associated with a high probability of developmental disability. In the past two years, numerous pathophysiological studies have attempted to define the pathogenesis of IVH. It has been speculated that there are at least four factors that may be responsible for its