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November 25, 1992

Future Trends in Allergy and Immunology

JAMA. 1992;268(20):2991-2992. doi:10.1001/jama.1992.03490200243030

AS PREDICTED by Salvaggio and Austen1 in the final chapter of the 1987 edition of the JAMA primer, many contributions to medicine continue to emerge from research in the field of allergy and immunology.1-4 Precise and sensitive immunologic laboratory techniques, including enzyme-linked immunoassays, immunoblot techniques, the polymerase chain reaction, and computerized cell sorting, have been developed to characterize, quantify, and separate the various leukocyte populations for diagnostic and therapeutic purposes. Among the newly emerged treatments are (1) use of antilymphocyte and antithymocyte globulin to support bone marrow transplantation; (2) isolation and administration of lymphokine-activated killer cells and tumor-infiltrating lymphocytes to selectively destroy certain forms of cancer; (3) use of monoclonal antibodies to overcome gram-negative sepsis; and (4) use of interferon alfa to control Kaposi's sarcoma and chronic hepatitis B infection and use of interferon gamma to control hepatitis C infection.

Identification and characterization of the inflammatory nature of