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November 15, 1985

From the NIH: Estrogen may protect against lung disorder

JAMA. 1985;254(19):2721. doi:10.1001/jama.1985.03360190027004

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Recent studies at Stanford (Calif) University suggest that three different genera of yeast either produce hormonelike substances or have receptors that bind human hormones. Since several of the types of yeast studied cause disease in humans, the researchers have been examining how the hormonal environment of the host may influence the pathogenesis of these diseases.

David Feldman, MD, working with David Stevens, MD, of the Santa Clara Valley Medical Center, San Jose, Calif, and Angela Restrepo, PhD, of the Corporacion De Investigaciones Biologicas, Medellin, Colombia, have found an estradiol-binding protein in the infectious yeast Paracoccidioides brasiliensis. The presence of the protein probably explains the pattern of pathogenicity of this organism (Infec Immun 1984;46:346-353; Proc Nat Acad Sci USA 1983;80:7659-7663).

Working with grant support from the NIH's National Institute of General Medical Sciences and the National Institute of Allergy and Infectious Diseases, the researchers also have determined that the presence of