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December 20, 1985

Baboon-to-Human Cardiac Xenotransplantation in a Neonate

JAMA. 1985;254(23):3321-3329. doi:10.1001/jama.1985.03360230053022

This report details the first case of cardiac xenotransplantation in a neonate. The recipient, a victim of hypoplastic left heart syndrome (HLHS), survived 20 days. Autopsy findings are documented. The cardiac graft showed only traces of cell-mediated rejection. Graft failure appears to have resulted from a progressive, potentially avoidable humoral response, unmodified by immunosuppression. Cardiac allotransplantation and selective baboon-to-human xenotransplantation deserve further exploration as investigational therapy for neonatal HLHS.

(JAMA 1985;254:3321-3329)