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December 20, 1985

Xenografts: Review of the Literature and Current Status

Author Affiliations

From the Council on Scientific Affairs, Division of Evaluation and Nomenclature, American Medical Association, Chicago.

JAMA. 1985;254(23):3353-3357. doi:10.1001/jama.1985.03360230085030

In response to growing public and legislative interest in organ transplantation, the American Medical Association's Council on Scientific Affairs has convened an advisory panel to prepare state-of-the-art monographs on several of the central topics. The first report of the panel, approved by the Council in February 1985, reviews the experimental work with xenografts. This report summarizes the published experience with animal and human xenografts to date and discusses the mechanisms of xenograft rejection. The report concludes that the process of xenograft rejection qualitatively resembles allograft rejection, involving both cellular and humoral immune mechanisms, but differs quantitatively depending on the genetic disparity between donor and recipient. Relative beneficial effects of various immunosuppression regimens, including cyclosporin on xenograft survival in donor recipient models with varying genetic disparity, have not yet been studied in a critical fashion.

(JAMA 1985;254:3353-3357)