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December 27, 1985

Variations in Human Physiology

Author Affiliations

Indiana University School of Medicine Gary

JAMA. 1985;254(24):3482. doi:10.1001/jama.1985.03360240096046

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Dr R. M. Case, with the assistance of Drs Evans, Garland, Green, Little, Minors, and Waterhouse from the Department of Physiology, University of Manchester, England, has prepared a one-volume text in physiology. Different from the classical texts in physiology, its emphasis is on variations in physiology during exposure to environmental changes, such as pressure, temperature, altitude, time, and gravity; physiological adaptations during pregnancy, fetal and neonatal life, old age, exercise, and exposure to artificial environments; and changes in physiology during injury or shock.

This reviewer agrees with the authors on the need to study changes and permanent physiological adaptations under a variety of conditions. Under other conditions as well, where changes in anatomy are induced by trauma, disease states, or iatrogenic interventions, permanent physiological adaptations take place. In paraplegia or after nephrectomy, gastrectomy, lobectomy, or hysterectomy, usually alternate homeostatic mechanisms develop in response to endogenous or exogenous stimuli. It is