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January 20, 1993

Treatment of Mild Hypertension Study Shows Results Better When Drugs Abet Life-style Changes

JAMA. 1993;269(3):323-327. doi:10.1001/jama.1993.03500030015004

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COMBINED DRUG and life-style therapies do more than life-style changes alone to reduce blood pressure in people with so-called stage 1 hypertension, according to the results of a 5-year study.

One-third fewer heart attacks, strokes, and instances of angina pectoris and other minor cardiovascular problems occurred in people who took any one of five drugs and also lost weight, increased their physical activity, and/or cut their sodium chloride and alcohol intake than in those who made the living changes but did not take the drugs.

Richard H. Grimm, Jr, MD, associate professor, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, presented details of the Treatment of Mild Hypertension Study (TOMHS) at the 65th annual scientific sessions of the American Heart Association, held in New Orleans, La.

The study evaluated 345 women and 557 men, 45 to 69 years of age, at four clinical centers for 4½ years. Twenty percent of