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February 21, 1986

Androgen and Germ Cell Testicular Cancers

JAMA. 1986;255(7):906. doi:10.1001/jama.1986.03370070060025

To the Editor.—  There has been a recent increase in androgen use by athletes and body builders. The long-term effects of androgen abuse in this young male population are unclear.

Report of a Case.—  A 36-year-old man with a stage I seminoma had illicitly taken methyltestosterone (Android) from 1976 to 1984. He began using 10 mg per day and during the subsequent eight-year period increased his dose of androgen to 200 mg twice daily for the final two years. Initially the patient expressed "fantastic" sexual energy but after four years of androgen therapy, he began to experience erectile difficulty. In 1982, at our Sexual Dysfunction Clinic he was found to have normal nocturnal penile tumescence and a normal serum testosterone level. He did not have a history of cryptorchidism and the history of androgen abuse was not illicited. In July 1984, he noted painless enlargement and swelling of the right