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February 28, 1986

Rejected Landmarks: The Smoke Goes On

JAMA. 1986;255(8):1017-1018. doi:10.1001/jama.1986.03370080039013

To the Editor.—  In the May 24/31, 1985, issue of JAMA there is a LANDMARK ARTICLE by Drs Wynder and Graham1 with comment by Dr Jesse L. Steinfeld.2 Dr Wynder was a student at Washington University School of Medicine in St Louis and Dr Graham a world-famous professor of surgery at the same institution. Smoking histories were obtained from 605 men with an established diagnosis of lung cancer in a number of hospitals throughout the United States, and these were compared with histories of 780 men in the general population with similar age and economic distribution. They found strong but not conclusive evidence of the relationship of lung cancer to cigarette smoking.Of considerable note is the fact that the article in JAMA of May 27, 1950, that immediately follows the LANDMARK ARTICLE is entitled "Cancer and Tobacco Smoking" and was written by Morton L. Levin, Hyman Gold-stein,