[Skip to Content]
[Skip to Content Landing]
March 14, 1986

Leukopenia and Anergy as Predictors of AIDS-Reply

JAMA. 1986;255(10):1289. doi:10.1001/jama.1986.03370100083016

In Reply.—  Cohen and associates, in their accompanying letter, have collected WBC counts on more than 11,000 adult inmates of a division of the New York City jail and determined that approximately 2.5% were leukopenic. This is certainly consistent with our historical data.1 They have also determined that less than 10% of those who were leukopenic were also anergic. All 22 anergic inmates had a history of parenteral drug abuse. No data on human T-cell lymphotropic virus type III (HTLV-III) antibody appear to be available.Leukopenia, per se, does not seem to be predictive of anergy or other prodromal signs and symptoms associated with AIDS. The development of testing procedures for HTLV-III antibody permits identification of those who have been exposed to the virus associated with AIDS, of whom only a portion are either prodromal or overtly ill.2 Antibodies against HTLV-I, HTLV-II, and HTLV-III are prevalent among intravenous