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February 10, 1993

Multicenter Clinical Trials of AIDS Vaccines Scheduled to Get Under Way in Coming Months

JAMA. 1993;269(6):725. doi:10.1001/jama.1993.03500060019006

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SOME 320 volunteers, men and women from 18 to 60 years of age who are human immunodeficiency virus (HIV) antibody-negative but may belong to groups at high risk for this infection, are being recruited for clinical trials of two vaccines against the acquired immunodeficiency syndrome (AIDS).

But some National Institutes of Health (NIH) officials predict that it will be at least 2 more years before full-scale vaccine trials are in progress.

For now, these two vaccines will be tested in five US centers—Johns Hopkins University Center for Immunization, Baltimore, Md; St Louis (Mo) University School of Medicine; University of Rochester (NY) Medical Center; Vanderbilt University Medical Center, Nashville, Tenn; and the University of Washington School of Medicine, Seattle.

Pass Safety Tests  The two vaccines have undergone safety testing previously. They did not appear to produce unwanted side effects.The trials are double-blinded and placebo-controlled. They will test the ability of