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June 2, 1993

Focus in Glaucoma May Change From Keeping Fluid Out to Letting Fluid Out

JAMA. 1993;269(21):2711. doi:10.1001/jama.1993.03500210011004

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CONVENTIONAL wisdom and treatment may have to give way as new evidence suggests that glaucoma treatments may be aimed the wrong way.

Future therapy will likely be designed to clean out the trabecular meshwork encircling the cornea to allow fluid out, rather than to reduce the flow into the eye as most current treatments do. So suggest findings presented at a Research to Prevent Blindness science writers seminar in Universal City, Calif.

If theory is confirmed in an ongoing phase III multicenter trial, one new treatment aimed at the trabecular meshwork may be needed as infrequently as once a year, predicts one researcher.

"We know unequivocally that for all forms of glaucoma, it is not a disease of excess formation of fluid, it is a disease of impaired drainage," says David L. Epstein, MD, professor and chair of ophthalmology, Duke University Medical Center, Durham, NC.

Ted S. Acott, PhD, another