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October 9, 1996

Lipoprotein Patterns, Plaque, Homocysteine, and Hormones Among Ongoing Cardiology Studies

JAMA. 1996;276(14):1122-1127. doi:10.1001/jama.1996.03540140010004

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LOWERING DIETARY FAT to reduce heart disease risk may be more effective in pattern B men than in their pattern A brethren, some of whom may be affected adversely, says a University of California, Berkeley, researcher.

Pattern B is low-density lipoprotein (LDL) subclass pattern B, says Ronald M. Krauss, MD, head, molecular and nuclear medicine, Lawrence Berkeley National Laboratory. It's characterized by unusually small and compact LDL particles that are more likely than the larger LDL particles characteristic of pattern A to stick in the artery wall. These small particles are also more susceptible to oxidation, lower serum levels of the high-density lipoprotein (HDL) cholesterol fraction, and levels above 2.26 mmol/L (200 mg/dL) of triglycerides and apolipoprotein B, the major LDL protein.

Therefore, Krauss told the 23rd Health and Science Journalists Forum of the American Heart Association (AHA) in Portsmouth, NH, pattern B men appear to be at about 3-fold