—To reevaluate at age 8 years children who had participated during the first 3 years of life in a randomized clinical trial of special services for low-birthweight (LBW) premature infants.
—Follow-up of a randomized controlled trial of premature infants (<37 weeks' gestation), stratified by 2 LBW groups (lighter [<2000 g] and heavier [2001 2500 g]) and divided into intervention (n=377) and follow-up only (n=608) groups.
—Eight sites serving diverse populations.
—At age 8 years, 874 children were assessed: 336 in the intervention group and 538 in the follow-up only group.
—The 3-year intervention consisted of home visits (birth to 3 years), child development center services (ages 1 to 3 years), and parent group meetings (ages 1 to 3 years).
Primary Outcome Measures.
—Cognitive functioning (Weschler Intelligence Scale for Children-Ill; Peabody Picture Vocabulary Test-Revised); academic achievement (Woodcock-Johnson Tests of Achievement-Revised); and parental reports of school performance, behavior (Child Behavior Checklist), and health (Child General Health Survey).
—At age 8 years, in the entire cohort and in the lighter LBW stratum, the intervention and follow-up only groups were similar on all primary outcome measures. Differences favoring the intervention group were found within the heavier LBW group: full-scale IQ score (4.4 points higher, P=.007), verbal IQ score (4.2 points higher, P=.01 ), performance IQ score (3.9 points higher, P=.02), mathematics achievement score (4.8 points higher, P=.04), and receptive vocabulary score (6.7 points higher, P=.001 ). On a physical functioning subscale, the whole intervention group received less favorable ratings, while the lighter LBW intervention group had lower maternal ratings assessing social limitations caused by behavior.
—Although at age 8 years there were modest intervention-related differences in the cognitive and academic skills of heavier LBW premature children, attenuation of the large favorable effects seen at 3 years was observed in both the heavier and lighter LBW groups. This indicates a need to develop additional intervention strategies for LBW premature children that can provide sustained benefits.
McCarton CM, Brooks-Gunn J, Wallace IF, et al. Results at Age 8 Years of Early Intervention for Low-Birth-Weight Premature Infants: The Infant Health and Development Program. JAMA. 1997;277(2):126–132. doi:10.1001/jama.1997.03540260040033
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