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March 26, 1997

Relationship Between HLA-C Locus and Restenosis After Coronary Artery Balloon Angioplasty

Author Affiliations

From the Department of Cardiology, Juntendo University (Drs Watanabe, Yokoi, Fujiwara, Mokuno, Daida, and Yamaguchi), and Third Department of Internal Medicine, University of Tokyo (Dr Yamada), Tokyo, Japan.

JAMA. 1997;277(12):983-984. doi:10.1001/jama.1997.03540360051030

Objectives.  —To determine the relationship between human leukocyte antigen (HLA) loci and restenosis after percutaneous transluminal coronary angioplasty (PTCA).

Design and Setting.  —Cross-sectional study in patients treated by PTCA at Juntendo University Hospital, Tokyo, Japan.

Patients.  —A total of 65 patients (58 males and 7 females) with coronary artery stenosis who were consecutively selected between October 1994 and June 1995.

Main Outcome Measures.  —Significant relationships between the restenosis and the HLA-Cw1

Results.  —Among HLA-C locus, Cw1 was negatively related to restenosis (multivariate adjusted odds ratio, 0.19; 95% confidence interval, 0.06-0.63; P=.007).

Conclusions.  —In HLA typing, Cw1 may be a useful marker for the prediction of restenosis after PTCA.