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April 2, 1997

Magnitude and Duration of the Effect of Sepsis on Survival

Author Affiliations

for the Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group
From the Miami Veterans Affairs Medical Center and the Division of Pulmonary and Critical Care Medicine, University of Miami, Miami, Fla (Drs Quartin, Schein, and Kett); and Department of Veterans Affairs Cooperative Studies Program Coordinating Center, West Haven, Conn (Dr Peduzzi).

JAMA. 1997;277(13):1058-1063. doi:10.1001/jama.1997.03540370048035

Objective.  —To determine the magnitude and duration of the effects of sepsis on survival.

Design.  —Cohort study.

Setting.  —The 10 Department of Veterans Affairs Medical Centers of the Systemic Sepsis Cooperative Studies Group, which from 1983 to 1986 conducted the Department of Veterans Affairs Cooperative Study of Corticosteroids in Systemic Sepsis.

Patients.  —The septic population consisted of 1505 patients with evaluable data from the screening log of the Cooperative Study of Corticosteroids in Systemic Sepsis. All 91 830 nonpsychiatric, noninfected patients discharged from the participating medical centers between October 1,1984, and September 30,1985, were included in the control population.

Main Outcome Measure.  —Death through 8 years after the index hospitalization.

Results.  —On the basis of a proportional hazards model constructed from the demographic and illness characteristics of the control population, the septic population was at significant risk of dying of nonseptic causes (26% predicted 1-year mortality). In the septic population, the daily risk of dying exceeded predictions from this model for 5 years, and the hazard rate rose with increasing severity of the septic episode throughout the first year (P<.05). Among 30-day survivors, sepsis reduced the remaining mean life span from a predicted 8.03 years to 4.08 years.

Conclusions.  —Sepsis not only causes deaths acutely, but also increases the risk of death for up to 5 years after the septic episode even after comorbidities are accounted for. The risk of late death during the first year is associated with the severity of the septic episode.

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