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May 28, 1997

Usefulness of Oral Mucosal Transudate for HIV Antibody Testing

Author Affiliations

University Hospital of Valladolid Valladolid, Spain

JAMA. 1997;277(20):1592. doi:10.1001/jama.1997.03540440026017

To the Editor.  —We read the article by Ms Gallo and associates1 about the new oral specimen collection device for HIV testing with great interest. We would like to contribute our experience in diagnosis of HIV infection using fluids other than serum (ie, OMT and urine). We analyzed 185 paired serum, gingivocrevicular transudate, and urine samples from individuals infected with HIV-1 (69 of whom were Centers for Disease Control and Prevention [CDC] stage II, 15 CDC stage III, and 30 CDC stage IV) and 71 noninfected individuals, blood donors from the hematology service of our hospital. We used an oral device consisting of a cylinder of cotton wool without preservative (Salivette, Sarstedt, Leicester, United Kingdom). Sample preservation was ensured by refrigeration.Individuals participating in the study were informed about the importance of proper pad placement in the gingivocrevicular fold and also that the pad should be removed from the mouth when it