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May 28, 1997

More on Dietary Sodium and Blood Pressure

Author Affiliations

Northwestern University Medical School Chicago, Ill
University of Tennessee Memphis
St Louis University St Louis, Mo
National Heart, Lung and Blood Institute Bethesda, Md
Tulane University School of Public Health New Orleans, La

JAMA. 1997;277(20):1594-1595. doi:10.1001/jama.1997.03540440028025

To the Editor.  —Several statements in the letter by Dr Logan and colleagues1 on dietary sodium and blood pressure (BP) require clarification and correction. First, the authors assert "studies including Intersalt (particularly when data from the 4 primitive societies have been excluded) have found, however, no consistent relationship."1 In Intersalt analyses on individuals, results were consistent for 10 074 persons from all 52 samples and for 9343 persons from 48 samples (excluding 4 low-sodium samples); the multivariate controlled coefficients for the sodium-systolic BP relationship were—3.1 mm Hg (P<.001) and -3.2 mm Hg (P<.001), respectively for a 24-hour urinary sodium level 100 mmol/d lower (or -6.0 and -6.2 mm Hg without adjustment for body mass index).2 Results also were similar for nonhypertensives,2 indicating that "salt sensitivity" is prevalent throughout the population and is not confined mainly to hypertensives.In multivariate cross-population analyses (n=52 and n=48),