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July 23, 1997

Surveillance for Variant Strains of HIV: Subtype G and Group O HIV-1

Author Affiliations

Centers for Disease Control and Prevention Atlanta, Ga
Department of Health and Mental Hygiene, State of Maryland Baltimore

JAMA. 1997;278(4):292. doi:10.1001/jama.1997.03550040048035

To the Editor.  —The state of Maryland, as part of the Centers for Disease Control and Prevention's national surveillance for human immunodeficiency virus (HIV) variants, collects blood from a sample of persons with acquired immunodeficiency syndrome (AIDS) for determination of viral subtype. Two patients infected with HIV-1 variants have been identified: the first identified HIV-1 subtype G infection in the United States, and the second identified HIV-1 group O infection in the United States.1Patient 1 was a woman in her mid 30s who was born in West Africa; HIV infection was diagnosed in the United States in the early 1990s. The patient was likely exposed to HIV by heterosexual contact with an HIV-infected person in Africa. She had severe immunosuppression and AIDS-defining opportunistic illnesses, including recurrent pneumonia, esophageal candidiasis, toxoplasma encephalitis, and disseminated cytomegalovirus disease. Death was attributed to HIV disease, pancytopenia, and cavernous sinus thrombosis.Plasma from

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