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March 1, 1884


JAMA. 1884;II(9):248-249. doi:10.1001/jama.1884.02390340024013

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Paris, Feb. 8, 1884.

Prof. Germain Sée and Dr. Bochefontaine, his "chef de laboratoire" at the Hotel Dieu, lately undertook a series of experiments as to the physiological action of the sulphate of quinine, which were afterward compared with the results obtained clinically at the hospital. The following is a summary of their paper on the subject which was read at a recent meeting of the Academy of Sciences:

In the healthy human subject, the sulphate of quinine lowers the temperature to a very insignificant degree; the oxidations, however, undergo marked diminution; the pulse becomes slower, and the blood-pressure is lowered. In the typhic patient, the temperature is lowered after the first gramme, and particularly after the second gramme of quinine; it falls one degree and a half in six or eight hours, and the effect persists for a day and a half. The oxidations diminish in the same proportion.

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