In the following experiments the hydrochlorate of cocaine, prepared by Merck, of Darmstadt, was used. It is uncrystallized, of a dull white color, has a slightly bitter taste, nearly neutral reaction, and is very soluble in water, alcohol, ether and chloroform. The solutions used were all made with water, and were i, 2 and 4 per cent. in strength.
Local Action.—On the skin and mucous membrane: If the foot of a frog be immersed for a few minutes in a solution of cocaine (2 per cent.), very marked anæsthesia of the skin is produced; or, if a solution (2 or 4 per cent.) is applied to the mucous membrane of the mouth, the same action is observed.
On the eye: When a few drops of a 4 per cent. solution are instilled into the eye of a frog, there is caused, after a short time, almost complete anæsthesia of the
BIGGS HM. THE PHYSIOLOGICAL ACTION OF COCAINE ON THE COMMON FROG, WITH SPECIAL REFERENCE TO ITS ACTION ON ORGANS AND TISSUES.. JAMA. 1885;IV(3):57–62. doi:10.1001/jama.1885.02390780001001
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