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February 21, 1885


JAMA. 1885;IV(8):221. doi:10.1001/jama.1885.02390830025009

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Pittsburgh, Pa.

Editor of the Journal of the American Medical Association: 

Dear Sir:  —You spring the question in your editorial of the Journal of Feb. 7, 1885, Is tolerance of unusually large doses in any acute disease during its progress evidence that the remedy is indicated or acting favorably? Now this question is of interest to the medical profession at large, and as we can come to no conclusion except through facts and observations gathered at the bedside by the general profession, I take this opportunity to direct your attention to a few acute diseases, the treatment of which will prove conclusively the affirmative of your interrogation. It is well known to those who have treated yellow fever that there is a great tolerance and even demand on the part of the patient suffering from this disease for calomel and quinine, in large doses, and I can truthfully testify that

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