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In the London Lancet for April 21, 1883, Mr. Matthew Hay gives the details of an interesting case of dropsy treated by the use of concentrated solutions of saline cathartics. This was suggested to him by observing, during the course of an investigation of the physiological action of saline cathartics, the effect of the administration of such a cathartic on the concentration of the blood. He succeeded in "demonstrating from experiments on man and dogs that if the salt be given in a concentrated solution when the alimentary canal contains little or no fluid, it produces an almost immediate and very decided concentration of the blood, owing to the blood becoming deprived of a large amount of its water through the intestinal secretion which the salt excites." He found, however, that this concentration of the blood does not occur if the salt is dissolved in sufficient water, or if the
EGGLESTON WG. NOTE ON THE TREATMENT OF DROPSY BY CONCENTRATED SOLUTIONS OF SALINE CATHARTICS.. JAMA. 1885;IV(13):343–344. doi:10.1001/jama.1885.02390880007001b
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