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—Dr. Uhthoff,1 of Berlin, publishes two cases of well-marked central blindness associated with normal peripheral visual acuity, which he refers to lead poisoning. Both male patients, one 57 and the other 18 years old. Both came under his observation about a year after the commencement of the trouble. The optic-discs, especially the temporal halves, exhibited well-marked atrophic change, whilst the nasal halves, although paler than normal, exhibited a pinkish color. Both patients were markedly asthenopic, being able merely to count fingers at a distance of six or seven inches, and each eye exhibited a well-marked and relatively large central field of absolute blindness, whilst the peripheral vision was normal. The one of 18 years was a painter's apprentice, and was attacked one month after the commencement of his apprentisage. He had been working with white lead. At the outset his sight seemed to improve, but finally remained in the
Partial Optic Nerve Atrophy in Lead Poisoning. JAMA. 1884;III(5):129. doi:10.1001/jama.1884.02390540017003
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