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April 4, 1885


JAMA. 1885;IV(14):387-388. doi:10.1001/jama.1885.02390890023010

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The Physiological Action of the Sulphate of Cinchonamine—A New Method of Treating Intestinal Obstruction—A New Clinical Thermometer.

Professor Vulpian lately communicated a note to the Academy of Sciences, in the names of Professor Germain See and Dr. Bochefontaine, who had made a series of experiments to determine the physiological action of the sulphate of cinchonamine; the following are the conclusions arrived at by these gentlemen: Cinchonamine appears to have a powerful action on the heart, and it was observed that arrested action of the heart was an almost constant phenomenon resulting from the influence of that alkaloid. This occurs during diastole, a special feature which characterizes only a limited number of poisons, of which muscarine is an example. But when a drop of a solution of atropine was allowed to fall on the heart, the diastole was replaced by systole, whereas the effect of cinchonamine was

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