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Article
September 13, 1884

THE FORMATION OF POISONS BY MICRO-ORGANISMS. CONSIDERED IN RELATION TO THE PRODUCTION OF DISEASE.

JAMA. 1884;III(11):281-287. doi:10.1001/jama.1884.02390600001001
Abstract

[Presented in Section of Practical Medicine and Materia Medica of the American Medical Association, May, 1884.]

INTRODUCTION.

If we review the history of the observation and experiment that has been had, bearing on the relations of micro-organisms to the production of disease, we may formulate the following propositions:

1. Experiment and observation has shown that there are many varieties of micro-organisms that do not produce disease or injury; that the mere presence of these life forms is not sufficient to cause disease.

2. Experiment has, also, shown that there are certain varieties of micro-organisms that do uniformly induce disease when they obtain entrance into the bodies of animals, or men.

3. All through the experimentation on this subject it has been noticed that poisons have appeared in connection with the disease producing organisms.

4. These poisons seem to be a product of the micro-organisms; and while produced only in connection

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