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Probably the most exhaustive paper read before the American Surgical Association in 1884 was one by Dr. N. Senn, of Milwaukee, entitled " Experimental Researches on Cicatrization in Bloodvessels after Ligature." The pamphlet form of this paper, now before us, occupies 117 pages with the short discussion. The first forty-six pages are devoted to the history of the ligature, histology of bloodvessels, the various ligatures, and to the subject of thrombosis after ligature.
How is cicatricial tissue formed in bloodvessels after ligature? It is to the consideration of this question that the paper is mainly given. This process has been attributed to: 1. Adhesive inflammation and plastic exudation at the seat of the ligature without reference to any histological changes. 2. Fibrin. 3. White blood-corpuscles. 4. Red blood-corpuscles. 5. Immigration corpuscles. 6. Connective tissue. 7. Endothelia. It is of course unnecessary to dwell at any length upon the views of the
CICATRIZATION IN BLOODVESSELS AFTER LIGATURE. JAMA. 1885;IV(21):577–578. doi:10.1001/jama.1885.02390960017004
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