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June 13, 1885


JAMA. 1885;IV(24):665-666. doi:10.1001/jama.1885.02390990021007

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Dr. Archibald D. Macdonald, of Liverpool, raises a very important question in the British Medical Journal, of May 23, as to the elimination of uric acid by nitrite of amyl. On three occasions he has noticed that the administration of nitrite of amyl markedly increased the acidity of the urine, and caused a deposit of uric acid crystals. The first case was one of puerperal eclampsia, in which the drug was given to control the convulsions; the second was a control experiment, in which the administration of the drug caused a marked increase of the uric acid in the urine of a healthy man; and the third was one of gout, which was much benefitted by three administrations, and with the result that the uric acid was very much increased.

The three cases recorded by Dr. Macdonald are sufficient basis for some careful physiological work, in which to investigate the

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