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June 20, 1885


JAMA. 1885;IV(25):683-684. doi:10.1001/jama.1885.02391000011002

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The Cholera-Bacillus.  —(In the Journal of June 13th we gave a résumé of Mr. Watson Cheyne's methods of cultivating the cholera-bacillus. He shows that there are several stages of growth of the cholera-bacillus.) The existence of the straight stage of the cholera-bacillus is of great importance to bear in mind, as it is probably the form which may of the bacilli assume in the intestinal contents in the early period of cholera, and as it would be impossible to recognise them as cholera-bacilli by the microscope alone, more especially when mixed with other bacteria. Hence, the discrepancy between the microscopic estimate and the estimate by cultivation, with regard to the numbers of these bacilli present in any given case, a discrepancy not remarked by me alone, but by several other observers. Indeed, from the very first, Dr. Koch found it impossible to distinguish by the microscope alone,

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