During the last few months numerous writers in Germany and France have described the good effects of antipyrin in acute rheumatism. It has been said of it that it relieves the pain and allays the fever as quickly as does the salicylate of soda, and that under its influence the cutaneous redness over the affected joints, and their swelling, gradually but soon disappears.
All of these statements I can confirm by my experience during the last four months in some twenty cases.
I have used antipyrin in acute cases, also in those that were subacute and in the acute exacerbations of those that were chronic. I noticed early that the greatest and most rapid improvement was obtained in cases in which there was a rise of temperature above the normal.
The first case in which I used antipyrin was one of chronic rheumatism in which there was, at the time,
DAVIS NS. ANTIPYRIN IN RHEUMATISM; ITS VALUE AND MODE OF ACTION.. JAMA. 1887;IX(1):13–16. doi:10.1001/jama.1887.04360030012003
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