There are few questions of higher importance in practical therapeutics than that of topical medication of the lungs. In discussing this question we may start with the postulate that particles of matter can enter the alveoli with the inspired air, be deposited upon their walls, and taken thence into the circulating fluids of the lymph spaces and capillaries.
If carbonaceous particles floating in the inspired air can enter the pulmonary tissue until it is colored black, then the possibility of similar medicinal agents behaving in like manner must be conceded. These facts, first correctly interpreted by Bouckman in the lungs of miners in the Hartz mountains, have been abundantly confirmed by Löwe, Petrens, Traube, Zenker, Von Ins, and many other reliable observers. Nor can it be argued that the processes of anthracosis are too slow to make their application to therapeutics practical or fair. On the contrary, the absorption of
McCASKEY GW. A NEW METHOD OF INTRA-PULMONARY MEDICATION, WITH REMARKS UPON ITS USE WITH PNEUMATIC TREATMENT. Read in the Section on Medicine, Materia Medica and Therapeutics, at the Thirty-Eighth Annual Meeting of the American Medical Association, June 7, 1887. JAMA. 1887;IX(4):107–110. doi:10.1001/jama.1887.02400030011002a
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