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Article
February 6, 1886

COCAINE; WHAT WAS ITS INFLUENCE IN THE FOLLOWING CASE?

JAMA. 1886;VI(6):166. doi:10.1001/jama.1886.04250020026012

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Abstract

To the Editor of the Journal: 

Dear Sir.  —With the view of increasing the amount of clinical evidence as to the value and effects of cocaine, I submit the following history of a case treated in the Missouri State Lunatic Asylum No. 2:Esther C., admitted October 21, 1884; aged 39 years, married 20 years, mother of four children, youngest 2½ years old. She was a strong, healthy woman until four years after marriage, about which time she became affected with some uterine trouble, and was never strong and well afterwards. She had never any acute serious illness. Eighteen months previous to admission the first symptoms of mental derangement were observed, manifested by neglect of maternal and household duties, and by frequent attempts to leave home alone, by day and night. She became despondent and melancholy, feared injury and death, destroyed her clothing and the furniture, did not eat or

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