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In a physiological sense atropine and eserine are synonymous with the terms mydriatic and myotic. Each is a representative of the class to which it belongs. Duboisine is a more powerful mydratic than atropine, while pilocarpine is a greater irritant and a less powerful myotic than eserine. A few cases that have come to my notice recently, forcibly illustrating the misuse, or I might say the abuse, of these valuable remedial agents furnish me material as well as occasion for inviting the attention of the profession to this seemingly threadbare subject. The cases which I desire more especially to signalize at present were victims of the misapplied use of atropine. Some of them had been rendered hopelessly blind by a single drop of a solution of the drug. While it is Perhaps impossible, in hundreds of cases, to show that any possible harm has resulted from the empirical use or
J. W. THOMPSON. ATROPINE AND ESERINE IN OPHTHALMIC THERAPEUTICS.. JAMA. 1886;VI(14):365–368. doi:10.1001/jama.1886.04250040001001