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September 17, 1887


JAMA. 1887;IX(12):371-372. doi:10.1001/jama.1887.02400110019002

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Salol in Acute Articular Rheumatism and Acute Febrile Diseases.  —Salol was discovered by Professor von Nencki in Berne some years ago, but has hitherto been little used as a medicine. Sahli, of Berne, has recently recommended it strongly for the treatment particularly of acute articular rheumatism and acute infectious diseases. Herrlich, after thoroughly testing it, is convinced of its value. In salol there is an ether combination of 60 per cent. of salicylic acid and 40 per cent. carbolic acid. It is salicylic phenol ether. It is a white crystalline powder with an agreeable, slightly aromatic odor. Its taste is bitter. Salol bears a resemblance to fats as regards both its chemical composition and its physical properties. Like fat, it cannot be dissolved in water, but is easily soluble in alcohol, ether, and in volatile and fat oils. It possesses pronounced antiseptic qualities; equal, according to Nencki and Sieber, to

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