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Article
October 29, 1887

KREATIN AND KREATININ:—ARE THEY WASTE OR NUTRITIOUS PRODUCTS IN THE ORGANISM?

JAMA. 1887;IX(18):561. doi:10.1001/jama.1887.02400170017004
Abstract

This question is of interest not alone from a purely physiological point of view, but also from the clinical standpoint, since the substances are part of the extractives of beef extracts, and may play an active part in rendering the latter nutritious and stimulating. Kreatin is known to increase in muscle when it is made to contract. Kreatinin is found in the urine, where its amount increases when injected into the blood. It is also found in larger quantities in the renal secretions when a person lives upon meat than when upon a purely vegetable diet. Its quantity is also increased in acute diseases and in chronic anæmic disorders, and is diminished in convalescence.

Chemists generally assert that both of these substances are formed in the organism by oxidation of proteids, and that they are substances formed as intermediate products of the final conversion of proteids into urea, carbon dioxide,

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