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Beginning with a denial of the common statement that the use of any anæsthetic lessens the success of operative surgery, Dr. McGuire mentioned that chloroform is the popular anæsthetic used in France (except in Lyons), Germany (except in Vienna), and in Italy. In Great Britain, mixtures of ether and chloroform are principally used. In China, chloroform is chiefly used. In the United States, ether is the popular agent throughout the Northern and Northwestern States, while chloroform is the generally adopted anæsthetic of the Southern and Southwestern States. Thus it will be seen that throughout the civilized world, chloroform is much more generally used than ether. Combining the obstetrical cases in which anæsthetics are used with the surgical, it may be safely estimated that chloroform is used twenty times as often as ether as the anæsthetic—the two agents to which he restricted his paper. He predicted that when a full analysis of