For some two years I have been employing the salicylate of ammonium in some of the affections in which we have been accustomed to place our main reliance upon quinine, and I desire to submit the results of such experiments and my own conclusions.
Before doing so it may not be amiss to speak of the leading motive of such an investigation; its development, step by step, will appear later on. Briefly, the inadequacy of quinine in typhoid and remittent fevers and other grave affections to which it is commonly addressed, nay, its not infrequent harmfulness, raised the question in my mind years ago, whether it were not desirable to supersede it as an antipyretic by some other of at least equal power and free from its disadvantages and dangers. That many physicians have entertained the same question is amply attested by the multitude of substitutes that have been
BARNETT JR. SALICYLATE OF AMMONIUM IN THE TREATMENT OF TYPHOID AND SEPTIC FEVERS AND INFLAMMATIONS. JAMA. 1886;VII(24):654–657. doi:10.1001/jama.1886.04250120038002
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