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Hydriodate of Hyoscine is recommended by Dr. J. Mitchell Bruce as being the most convenient salt of the alkaloid for use as a cerebral sedative (Practitioner, pp. 321-333). He finds that it is best administered by subcutaneous injection in doses of 1/200 of a grain. Although it is usually only necessary to give one dose in the evening to secure a quiet night, in cases of high delirium it has been repeated within four or six hours with advantage and safety. If given by the mouth, larger doses are required, ās much as 1/120 to 1/90, or even 1/50 of a grain given at bedtime, having proved satisfactory in the hands of Dr. Wetherill, Jr. In America, 1/100 of a grain has been fixed upon as the average working dose. Mr. Freeman and Mr Hardy, of Charing Hospital, have, however, come to the conclusion that 1/200 of a grain of
MEDICAL PROGRESS.. JAMA. 1887;VIII(8):207–208. doi:10.1001/jama.1887.02391330011002
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