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In a most interesting paper in the St. Petersburger Medicinische Wochenschrift, No. 1, 1887, Trussewitsch recommends that in prescribing nitroglycerine the terms angioneurosin or aneurosin be substituted for the name which is so objectionable in some cases, since these terms clearly indicate the class of diseases in which the drug has been found most serviceable—diseases in which the vaso motor disturbances constitute the most important substratum.
A deviation of the arterial lumen from the normal vascular tone is a condition sine qua non to a successful employment of the drug, the dilating effect of which extends to the arterioles and the capillaries. But while the primary effect of the vaso constrictor nerves is the main indication, another of equal importance is found in the ischæmia, which secondarily follows upon an unequal distribution of the blood either from determination to or dilatation of certain vascular territories. A tonic vaso motor spasm
THE CONDITIONS FOR THE ADMINISTRATION OF NITROGLYCERINE.. JAMA. 1887;VIII(14):377–379. doi:10.1001/jama.1887.02391390013003