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April 16, 1887

EXOPHTHALMIC GOITRE: WITH REPORT OF A CASE.Read before the Illinois and Iowa Central District Medical Association. October 14, 1886.

JAMA. 1887;VIII(16):430-432. doi:10.1001/jama.1887.02391410010001b

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This affection is characterized by three prominent symptoms: protuberance of the eyeballs, enlargement of the thyroid body, and palpitation of the heart. The name, exophthalmic goitre, relates to the first two of these symptoms. That it is defective, is proven by its failure to include the increased frequency of the heart's action, which is almost invariably the initial symptom, and is the only one of the so-called symptomatic triad which is never absent. Although ophthalmologists, like Demours, Mackenzie, Sichel and Desmarres, had already made mention of this affection, it remained for Graves to describe it as an individual complaint, which he did in 1835. Afterwards, from Basedow giving a fuller description of it, it was known as Basedow's disease, which is the name now given to the affection by German writers. American, English and French writers have adopted the name Graves' disease, as proposed by Trousseau. Cardiogmus strumosus, and exophthalmic

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