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Recent Researches in Diuretics.
—To what extent the Malpighian corpuscles and the renal tubules respectively take part in the secretion of urine, is not yet accurately known, although the researches of Heidenhain, Nussbaum, and others, have added much to our knowledge. It seems likely that an investigation into the mode of action of diuretics will throw great light on the question, because a diuretic drug may act either on the Malpighian corpuscles, increasing the flow of urinary water, or on the renal tubules, increasing the amount of urinary solids, or on both structures. The great difficulty, however, in experiments on the kidney in living animals, is that of estimating how much of the effect produced by a drug is due to changes in the circulation, or in the nervous system, which has an influence on the secretory activity of the kidney, as well as on the blood-vessels. Munk has, in
MEDICAL PROGRESS.. JAMA. 1887;VIII(21):571–572. doi:10.1001/jama.1887.02391460011002