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May 28, 1887


JAMA. 1887;VIII(22):599-600. doi:10.1001/jama.1887.02391470011002

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Diagnosis of Brain Diseases.  Nothnagel, in a recent article read before the College of Physicians of Vienna, gave the following diagnostic points of brain disease:

  1. In brain tumors headache is of very little value in diagnosis; the cerebral substance is not sensitive; the pia mater but little sensitive and the dura mater only, of the cranial contents, is sensitive. Headache in cases of cerebral tumor is explained by tension on the dura caused by the bulk of the tumor.

  1. Headache is present in inflammatory processes in the meninges, and more frequently in lepto-meningitis than in pachymeningitis; in lepto-meningitis the headache frequently changes its character.

  1. Headache is present in chronic cerebral hyperæmia and chronic anæmia; it is questionable whether anæmia alone is the important element in chlorosis, as most marked cases of pernicious and intensive anæmia are caused by carcinoma in which headache is absent. Headache is

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