Especially through the establishment of the pathologic anatomy of the condition, a general agreement has been reached that puerperal eclampsia must be included among the diseases caused by toxic materials of unknown origin and nature, and that it is not so closely related to ordinary uremia as it is to such a distinctly toxemic condition as acute yellow atrophy. More recently it has become recognized that certain of the cases of pernicious vomiting of pregnancy are of similar nature, this fact having been established through the valuable studies of Williams.
In acute yellow atrophy, which is so frequently to be considered as a toxemic result of pregnancy, we have, as is well known, extensive necrosis in the liver, beginning in the centers of the lobules and spreading outward, while the clinical manifestations are those of a profound toxemia. Puerperal eclampsia is also accompanied by extensive degenerative changes in the liver,
THE TOXEMIAS OF PREGNANCY.. JAMA. 1908;L(2):124–125. doi:10.1001/jama.1908.02530280040006
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