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Antipyrin and Antifebrin in Headache and Epilepsy.
—In a paper on this subject Dr. Allen McLane Hamilton says: In January last Ungar related his experience with antipyrin in the treatment of hemicrania, and in March Dr. C. B. Lyman, who had been induced to try the remedy after the publication of Ungar's success, administered it in several cases of neuralgia of the cervical, facial, and supra-orbital or mixed varieties, with more or less benefit. The first of these observers experimented with it as a successor to the salicylates, which have proved to be of great value in his hands in several varieties of headache, and he witnessed no evil results from doses of even 23 grains. Lyman used an initial dose of 15 grains, repeated two or three times if necessary, and relieved the paroxysms, but did not prevent their recurrence. In March last I began a trial of this
MEDICAL PROGRESS.. JAMA. 1887;VIII(25):681–682. doi:10.1001/jama.1887.02391500009003
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