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January 25, 1908

THE APPEARANCE OF GLYCURONIC ACID IN CERTAIN CONDITIONS OF DIMINISHED OXIDATION.

JAMA. 1908;L(4):252-254. doi:10.1001/jama.1908.25310300004001a
Abstract

Considerable scientific interest has recently been aroused with reference to the origin and importance of glycuronic acid or its conjugate salts in carbohydrate metabolism, and especially in diabetes mellitus. Paul Mayer, in a series of papers, advanced the view that since glycuronic acid represents the first step in the progressive oxidation of dextrose into CO2 and H2O, this compound would necessarily appear as an incompletely oxidized product of dextrose combustion when, as in the incipient stages of diabetes, the body was beginning to lose its power to oxidize the carbohydrates. In substantiation of this Mayer1 presented the results of the study of some cases of so-called incipient diabetes and of dyspnea in which he detected the elimination of glycuronates in quantities far in excess of the normal. So far as I am aware, no further notice of this point has been taken clinically, although, theoretically considered,

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